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Oct 5, 2014
10/14
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Yeh, Fang-Cheng; Parwani, Anil V.; Pantanowitz, Liron; Ho, Chien
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Introduction:: Recent technology developments have demonstrated the benefit of using whole slide imaging (WSI) in computer-aided diagnosis. In this paper, we explore the feasibility of using automatic WSI analysis to assist grading of clear cell renal cell carcinoma (RCC), which is a manual task traditionally performed by pathologists. Materials and Methods:: Automatic WSI analysis was applied to 39 hematoxylin and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141422
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Oct 23, 2014
10/14
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Yeh, Fang-Cheng; Ye, Qing; Hitchens, T. Kevin; Wu, Yijen L.; Parwani, Anil V.; Ho, Chien
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eye 14
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Whole slide imaging (WSI) offers a novel approach to digitize and review pathology slides, but the voluminous data generated by this technology demand new computational methods for image analysis. Materials and Methods:: In this study, we report a method that recognizes stains in WSI data and uses kernel density estimator to calculate the stain density across the digitized pathology slides. The validation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952401
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Sep 30, 2014
09/14
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Rohde, Gustavo K.; Ozolek, John A.; Parwani, Anil V.; Pantanowitz, Liron
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eye 19
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Recent advances in digital imaging is impacting the practice of pathology. One of the key enabling technologies that is leading the way towards this transformation is the use of whole slide imaging (WSI) which allows glass slides to be converted into large image files that can be shared, stored, and analyzed rapidly. Many applications around this novel technology have evolved in the last decade including education,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168545
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Sep 30, 2014
09/14
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Pantanowitz, Liron; Parwani, Anil V.
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eye 18
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This article is from Journal of Pathology Informatics , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168641
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Oct 23, 2014
10/14
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Baron, Jason M.; Dighe, Anand S.; Arnaout, Ramy; Balis, Ulysses J.; Black-Schaffer, W. Stephen; Carter, Alexis B.; Henricks, Walter H.; Higgins, John M.; Jackson, Brian R.; Kim, JiYeon; Klepeis, Veronica E.; Le, Long P.; Louis, David N.; Mandelker, Diana; Mermel, Craig H.; Michaelson, James S.; Nagarajan, Rakesh; Platt, Mihae E.; Quinn, Andrew M.; Rao, Luigi; Shirts, Brian H.; Gilbertson, John R.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Pathologists and informaticians are becoming increasingly interested in electronic clinical decision support for pathology, laboratory medicine and clinical diagnosis. Improved decision support may optimize laboratory test selection, improve test result interpretation and permit the extraction of enhanced diagnostic information from existing laboratory data. Nonetheless, the field of pathology decision...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952400
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Oct 22, 2014
10/14
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Mandelker, Diana; Lee, Roy E.; Platt, Mia Y.; Riedlinger, Gregory; Quinn, Andrew; Rao, Luigi K. F.; Klepeis, Veronica E.; Mahowald, Michael; Lane, William J.; Beckwith, Bruce A.; Baron, Jason M.; McClintock, David S.; Kuo, Frank C.; Lebo, Matthew S.; Gilbertson, John R.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude with information fundamentals, information systems, workflow and process, and governance and management. Currently, many of those seeking training in pathology informatics...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023031
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Oct 23, 2014
10/14
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Bautista, Pinky A.; Hashimoto, Noriaki; Yagi, Yukako
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Color consistency in histology images is still an issue in digital pathology. Different imaging systems reproduced the colors of a histological slide differently. Materials and Methods:: Color correction was implemented using the color information of the nine color patches of a color calibration slide. The inherent spectral colors of these patches along with their scanned colors were used to derive a color...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952402
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Oct 22, 2014
10/14
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Mohammed, Emad A.; Mohamed, Mostafa M. A.; Far, Behrouz H.; Naugler, Christopher
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eye 21
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Peripheral blood smear image examination is a part of the routine work of every laboratory. The manual examination of these images is tedious, time-consuming and suffers from interobserver variation. This has motivated researchers to develop different algorithms and methods to automate peripheral blood smear image analysis. Image analysis itself consists of a sequence of steps consisting of image segmentation, features...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023032
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Oct 22, 2014
10/14
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Bernard, Chantal; Chandrakanth, S. A.; Cornell, Ian Scott; Dalton, James; Evans, Andrew; Garcia, Bertha M.; Godin, Chris; Godlewski, Marek; Jansen, Gerard H.; Kabani, Amin; Louahlia, Said; Manning, Lisa; Maung, Raymond; Moore, Lisa; Philley, Joanne; Slatnik, Jack; Srigley, John; Thibault, Alain; Picard, Donald Daniel; Cracower, Hanah; Tetu, Bernard
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eye 24
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This article is from Journal of Pathology Informatics , volume 5 . Abstract The use of telepathology for clinical applications in Canada has steadily become more attractive over the last 10 years, driven largely by its potential to provide rapid pathology consulting services throughout the country regardless of the location of a particular institution. Based on this trend, the president of the Canadian Association of Pathologists asked a working group consisting of pathologists, technologists,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023030
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Oct 22, 2014
10/14
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Hartman, Douglas J.; Parwani, Anil V.; Cable, Bill; Cucoranu, Ioan C.; McHugh, Jeff S.; Kolowitz, Brian J.; Yousem, Samuel A.; Palat, Vijaykumar; Reden, Anna Von; Sloka, Stephen; Lauro, Gonzalo Romero; Ahmed, Ishtiaque; Pantanowitz, Liron
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Introduction:: Telepathology allows the digital transmission of images for rapid access to pathology experts. Recent technologic advances in smartphones have allowed them to be used to acquire and transmit digital images of the glass slide, representing cost savings and efficiency gains over traditional forms of telepathology. We report our experience with developing an iPhone application (App - Pocket Pathologist) to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023036
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Oct 5, 2014
10/14
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Thrall, Michael J.; Rivera, Andreana L.; Takei, Hidehiro; Powell, Suzanne Z.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Robotic telepathology (RT) allows a remote pathologist to control and view a glass slide over the internet. This technology has been demonstrated to be effective on several platforms, but we present the first report on the validation of RT using the iScan Coreo Au whole slide imaging scanner. Methods:: One intraoperative touch preparation slide from each of 100 cases were examined twice (200 total cases)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141358
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Sep 30, 2014
09/14
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Azzato, Elizabeth M.; Morrissette, Jennifer J. D.; Halbiger, Regina D.; Bagg, Adam; Daber, Robert D.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: At some institutions, including ours, bone marrow aspirate specimen triage is complex, with hematopathology triage decisions that need to be communicated to downstream ancillary testing laboratories and many specimen aliquot transfers that are handled outside of the laboratory information system (LIS). We developed a custom integrated database with dashboards to facilitate and streamline this workflow....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168549
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Oct 22, 2014
10/14
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Toth, Robert J.; Shih, Natalie; Tomaszewski, John E.; Feldman, Michael D.; Kutter, Oliver; Yu, Daphne N.; Paulus, John C.; Paladini, Ginaluca; Madabhushi, Anant
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eye 22
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Context:: Co-registration of ex-vivo histologic images with pre-operative imaging (e.g., magnetic resonance imaging [MRI]) can be used to align and map disease extent, and to identify quantitative imaging signatures. However, ex-vivo histology images are frequently sectioned into quarters prior to imaging. Aims:: This work presents Histostitcher™, a software system designed to create a pseudo whole mount histology...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023035
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Oct 14, 2014
10/14
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Mahe, Etienne R.; Higa, Diane; Naugler, Christopher; Mansoor, Adnan; Shabani-Rad, Meer-Taher
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eye 18
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Context:: Many hematology laboratories have adopted semi-automated digital platforms for routine use and the evidence supporting their use is increasing. Aims:: The CellaVision platforms are among the most thoroughly studied digital hematology platforms; we wished to determine the accuracy of CellaVision for reticulocyte counting. Design, Materials and Methods:: We compared reticulocyte counts performed manually, using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060401
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Oct 5, 2014
10/14
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Hassell, Lewis A.; Wagar, Elizabeth A.
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eye 17
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This article is from Journal of Pathology Informatics , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141420
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Oct 5, 2014
10/14
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Bhagavatula, Ramamurthy; McCann, Michael T.; Fickus, Matthew; Castro, Carlos A.; Ozolek, John A.; Kovacevic, Jelena
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eye 17
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This article is from Journal of Pathology Informatics , volume 5 . Abstract We propose a methodology for the design of features mimicking the visual cues used by pathologists when identifying tissues in hematoxylin and eosin (H&E)-stained samples.Background:: H&E staining is the gold standard in clinical histology; it is cheap and universally used, producing a vast number of histopathological samples. While pathologists accurately and consistently identify tissues and their pathologies,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141425
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Oct 5, 2014
10/14
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Nelson, Heidi D.; Weerasinghe, Roshanthi; Martel, Maritza; Bifulco, Carlo; Assur, Ted; Elmore, Joann G.; Weaver, Donald L.
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eye 20
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Health care systems rely on electronic patient data, yet access to breast tissue pathology results continues to depend on interpreting dictated free-text reports. Objective:: The objective was to develop a method to electronically search and categorize pathologic diagnoses of patients’ breast tissue specimens from dictated free-text pathology reports in a large health system for multiple users including...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141424
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Oct 22, 2014
10/14
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Thorstenson, Sten; Molin, Jesper; Lundstrom, Claes
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eye 15
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Recent technological advances have improved the whole slide imaging (WSI) scanner quality and reduced the cost of storage, thereby enabling the deployment of digital pathology for routine diagnostics. In this paper we present the experiences from two Swedish sites having deployed routine large-scale WSI for primary review. At Kalmar County Hospital, the digitization process started in 2006 to reduce the time spent at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023034
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Oct 22, 2014
10/14
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Krasowski, Matthew D.; Davis, Scott R.; Drees, Denny; Morris, Cory; Kulhavy, Jeff; Crone, Cheri; Bebber, Tami; Clark, Iwa; Nelson, David L.; Teul, Sharon; Voss, Dena; Aman, Dean; Fahnle, Julie; Blau, John L.
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eye 30
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Autoverification is a process of using computer-based rules to verify clinical laboratory test results without manual intervention. To date, there is little published data on the use of autoverification over the course of years in a clinical laboratory. We describe the evolution and application of autoverification in an academic medical center clinical chemistry core laboratory. Subjects and Methods:: At...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023033
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Oct 5, 2014
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Roy, Somak; Pantanowitz, Liron; Amin, Milon; Seethala, Raja R.; Ishtiaque, Ahmed; Yousem, Samuel A.; Parwani, Anil V.; Cucoranu, Ioan; Hartman, Douglas J.
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eye 30
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Photomicrographs in Anatomic Pathology provide a means of quickly sharing information from a glass slide for consultation, education, documentation and publication. While static image acquisition historically involved the use of a permanently mounted camera unit on a microscope, such cameras may be expensive, need to be connected to a computer, and often require proprietary software to acquire and process...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141421
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Sep 30, 2014
09/14
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Bredfeldt, Jeremy S.; Liu, Yuming; Conklin, Matthew W.; Keely, Patricia J.; Mackie, Thomas R.; Eliceiri, Kevin W.
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eye 18
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Mortality in cancer patients is directly attributable to the ability of cancer cells to metastasize to distant sites from the primary tumor. This migration of tumor cells begins with a remodeling of the local tumor microenvironment, including changes to the extracellular matrix and the recruitment of stromal cells, both of which facilitate invasion of tumor cells into the bloodstream. In breast cancer, it...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168643
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Oct 22, 2014
10/14
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Dutta-Moscato, Joyeeta; Gopalakrishnan, Vanathi; Lotze, Michael T.; Becich, Michael J.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract This editorial provides insights into how informatics can attract highly trained students by involving them in science, technology, engineering, and math (STEM) training at the high school level and continuing to provide mentorship and research opportunities through the formative years of their education. Our central premise is that the trajectory necessary to be expert in the emergent fields in front of them requires...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030307
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Sep 30, 2014
09/14
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Pantanowitz, Liron; Krupinski, Elizabeth A.
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eye 16
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This article is from Journal of Pathology Informatics , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168546
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Oct 23, 2014
10/14
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Tuthill, J. Mark; Friedman, Bruce A.; Balis, Ulysses J.; Splitz, Andrew
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eye 21
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This article is from Journal of Pathology Informatics , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986538
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Oct 5, 2014
10/14
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Quinn, Andrew M.; Klepeis, Veronica E.; Mandelker, Diana L.; Platt, Mia Y.; Rao, Luigi K. F.; Riedlinger, Gregory; Baron, Jason M.; Brodsky, Victor; Kim, Ji Yeon; Lane, William; Lee, Roy E.; Levy, Bruce P.; McClintock, David S.; Beckwith, Bruce A.; Kuo, Frank C.; Gilbertson, John R.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract The Partners HealthCare system's Clinical Fellowship in Pathology Informatics (Boston, MA, USA) faces ongoing challenges to the delivery of its core curriculum in the forms of: (1) New classes of fellows annually with new and varying educational needs and increasingly fractured, enterprise-wide commitments; (2) taxing electronic health record (EHR) and laboratory information system (LIS) implementations; and (3)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141423
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Oct 24, 2014
10/14
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Ping, Zheng; Siegal, Gene P.; Almeida, Jonas S.; Schnitt, Stuart J.; Shen, Dejun
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Genetics and genomics have radically altered our understanding of breast cancer progression. However, the genomic basis of various histopathologic features of breast cancer is not yet well-defined. Materials and Methods:: The Cancer Genome Atlas (TCGA) is an international database containing a large collection of human cancer genome sequencing data. cBioPortal is a web tool developed for mining these...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952399
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Oct 5, 2014
10/14
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Diaz-Perez, Julio A.; Raju, Sharat; Echeverri, Jorge H.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Learning pathology is fundamental for a successful medical practice. In recent years, medical education has undergone a profound transformation toward the development of an integrated curriculum incorporating both basic science and clinical material. Simultaneously, there has been a shift from a magisterial teaching approach to one centered around problem-based learning. Now-a-days, informatics tools are...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141419
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Oct 23, 2014
10/14
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Friedberg, Richard C.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986537
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Oct 23, 2014
10/14
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Reyes, Carolina; Ikpatt, Offiong F.; Nadji, Mehrdad; Cote, Richard J.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Automated whole slide imaging (WSI), also known as virtual microscopy is rapidly becoming an important tool in diagnostic pathology. Currently, the primary utilization of the technique is for transmission of digital images, for second opinion consultation, as well as for quality assurance and education. The high-resolution of digital images along with the refinement of technology could now allow for WSI to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986536
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Sep 30, 2014
09/14
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Ho, Jonhan; Ahlers, Stefan M.; Stratman, Curtis; Aridor, Orly; Pantanowitz, Liron; Fine, Jeffrey L.; Kuzmishin, John A.; Montalto, Michael C.; Parwani, Anil V.
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: Digital pathology offers potential improvements in workflow and interpretive accuracy. Although currently digital pathology is commonly used for research and education, its clinical use has been limited to niche applications such as frozen sections and remote second opinion consultations. This is mainly due to regulatory hurdles, but also to a dearth of data supporting a positive economic cost-benefit....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168664
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Oct 14, 2014
10/14
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Braunhut, Beth L.; Graham, Anna R.; Lian, Fangru; Webster, Phyllis D.; Krupinski, Elizabeth A.; Bhattacharyya, Achyut K.; Weinstein, Ronald S.
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eye 15
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Background:: The case triage practice workflow model was used to manage incoming cases on a telepathology-enabled surgical pathology quality assurance (QA) service. Maximizing efficiency of workflow and the use of pathologist time requires detailed information on factors that influence telepathologists’ decision-making on a surgical pathology QA service, which was gathered and analyzed in this study. Materials and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060405
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Oct 14, 2014
10/14
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Cucoranu, Ioan C.; Parwani, Anil V.; Vepa, Suryanarayana; Weinstein, Ronald S.; Pantanowitz, Liron
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This article is from Journal of Pathology Informatics , volume 5 . Abstract Introduction:: Digital pathology is a relatively new field. Inventors of technology in this field typically file for patents to protect their intellectual property. An understanding of the patent landscape is crucial for companies wishing to secure patent protection and market dominance for their products. To our knowledge, there has been no prior systematic review of patents related to digital pathology. Therefore, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060404
